Parallel Genetic Changes and Nonparallel Gene–Environment Interactions Characterize the Evolution of Drug Resistance in Yeast
نویسندگان
چکیده
منابع مشابه
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of drug resistance in yeast.
Beneficial mutations are required for adaptation to novel environments, yet the range of mutational pathways that are available to a population has been poorly characterized, particularly in eukaryotes. We assessed the genetic changes of the first mutations acquired during adaptation to a novel environment (exposure to the fungicide, nystatin) in 35 haploid lines of Saccharomyces cerevisiae. Th...
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ژورنال
عنوان ژورنال: Genetics
سال: 2012
ISSN: 1943-2631
DOI: 10.1534/genetics.112.142620